As part of ongoing efforts under the planetGOLD Ghana Project to mitigate the health and environmental impacts of mercury use in Artisanal and Small-Scale Gold Mining (ASGM), a one-day Trainer of Trainers (TOT) workshop was organized for selected health professionals from Tarkwa-Nsuaem, Prestea-Huni Valley, and Wassa Amenfi West Municipalities. The workshop aimed to enhance participants’ understanding of mercury exposure pathways, strengthen their skills in clinical recognition of mercury-related illnesses, and build capacity for prevention, health promotion, and community education.